Venient Fx Iron Function Basic
Test Description
Venient Fx Iron Function Basic is a disruptive, non-invasive test that provides essential information about a patient's iron transport and storage function.
Based on a routine blood test and powered by both proprietary machine learning and public algorithms, it provides highly accurate primary diagnostic information, including the likelihood of anemia. As a first line test, the measured parameter results guide through diagnostic, prognostic and therapeutic options. Although the results are usually preliminary in decision making, in some cases, they can be definitive.
It is based on the measurement of important parameters in the assessment of anemia risk, such as red blood cell indices, blood cell counts, and serum iron. In addition, it also includes other determinations such as liver enzymes, different types of cholesterols, glucose and total and direct bilirubin, among others.
In case of a positive result, the diagnostic report suggests the performance of a specific secondary test of choice, in order to deepen the diagnostic information, confirm therapeutic approaches, establish prognoses or follow up the disease.
If anemia is suggested, other tests will be recommended as appropriate.
Screening recommendations
The United States Preventative Services Task Force (USPSTF) recommends routine screening for iron deficiency anemia in asymptomatic pregnant women.
However, Kience Inc. recommends the Venient Fx Iron Function Basic test to treat patients with the following symptoms, signs or suspected disease: iron deficiency, vitamin B12 deficiency, folic acid deficiency, hemolytic anemia, chronic kidney disease, myelodysplastic syndromes, dietary deficiencies, hypothyroidism, celiac disease, gastrointestinal angiodysplasia, atrophic gastritis, medullary aplasia, myelophthasic anemia, alcoholism, hypersplenism, pregnancy-related anemia, thrombotic microangiopathy, mechanical hemolysis caused by prosthetic valve dysfunction or thalassemia, among others.
Intended Use
The target population for Venient Fx Iron Function Basic is patients with clinical suspicion of: iron deficiency, vitamin B12 deficiency, folic acid deficiency, hemolytic anemia, chronic kidney disease, chronic kidney disease, myelodysplastic syndromes, dietary deficiencies, hypothyroidism, celiac disease, gastrointestinal angiodysplasia, myelophthisic anemia, alcoholism, hypersplenism, thrombotic microangiopathy, mechanical hemolysis caused by prosthetic valve dysfunction or thalassemia.
Sample Clinical Vignette
A 55-year-old female goes to her healthcare provider, because of shortness of breath, tiredness and fragile and easily broken nails. She also relates the symptomatology to as soon as she decided to start on an exclusive vegan diet. Physical exam reveals mucous pallor, mild tachycardia (110 bpm) and hemoglobin of 6.7 g/L in a previous sample. A blood sample is submitted to determine the anemia and the type of anemia.
Required Laboratory Determinations
Hemogram —Red Blood Cell Count, Hemoglobin, Hematocrit—; Red Blood Cell Indices —Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Blood Distribution Width (RDW)—; Leukocyte Count —Total Leukocytes Absolute, Total Neutrophil Absolute, Total Lymphocyte Absolute, Total Monocyte Absolute, Total Eosinophil Absolute, Total Basophil Absolute—; Platelets —Total Platelet Count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW)—; Serum Hepatic Enzymes —Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase (LDH)—; Serum Sterols & Fatty Acids —Total Cholesterol, HDL-Cholesterol, Cholesterol non-HDL, LDL-Cholesterol, VLDL-Cholesterol, Triglycerides—; Other Serum Analytes —Bilirubin Total, Bilirubin Direct, Bilirubin Indirect, Serum Creatinine, Glucose, Serum Iron, Urea, Blood Urea Nitrogen, Uric Acid—.