Venient Fx Hydroelectrolytic Metabolism Comprehensive

Test Description
Venient Fx Hydroelectrolytic Metabolism Comprehensive is a groundbreaking blood-based screening test that provides extensive information about the electrolytic balance — also known as water-electrolyte balance —, primarily based on the electrolyte profile (bicarbonate, calcium, chloride, mangesium, phosphorus, potassium, and sodium). 

This is an Evidence-Based Laboratory Medicine (EBLM) test developed not only in compliance with the American Association of Clinical Endocrinology (AACE) and the National Kidney Foundation (NKF) guidelines, but also incorporating the latest scientific findings. Thanks to our proprietary machine learning (ML) algorithms, this test is able to accurately detect a wide range of electrolyte imbalance-related diseases, e.g., hypocalcemia, hypermagnesemia, or hyponatremia, among others, and deliver comprehensive information. 

United States Preventative Services Task Force (USPSTF) screening recommendations
Currently, there is no USPSTF screening recommendation for electrolytes imbalances. However, Kience Inc. recommends our laboratory-developed test (LDT) Venient Cx Hydroelectrolytic Metabolism Comprehensive to target patients in the diagnosis or follow-up of these diseases: acute kidney injury (AKI), chronic kidney disease (CKD), drug-induced dyselectrolytemia, dehydration (e.g. prolonged vomiting and diarrhea), adrenal pathology, renal tubular an non-tubular diseases, hypoparathyroidism, excessive use of laxatives, primary polydipsia, or second or third-degree burns, among others.

Intended Use
The intended use population for Venient Cx Hydroelectrolytic Metabolism Comprehensive test are patients in the diagnosis or follow-up of these diseases: acute kidney injury (AKI), chronic kidney disease (CKD), drug-induced dyselectrolytemia, dehydration (e.g. prolonged vomiting and diarrhea), adrenal pathology, renal tubular and non-tubular diseases, hypoparathyroidism, excessive use of laxatives or diuretics, primary polydipsia or second or third-degree burns.

Sample Clinical Vignette
A 78-year-old male with a previous antecedents of hypertension and heart failure with low ejection fraction that requires diuretics, presented for medical evaluation after a 1-week history of nausea, general malaise, headache and drowsiness. Physical exam revealed low blood pressure (85/40 mmHg), mild dehydration, mild bradypsychia and chronic edema of the lower limbs. Serum is submitted to detect ion-balance disorders related with the use of diuretics.

Required Laboratory Determinations
Serum Electrolytes —Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium—; Serum Proteins —Albumin—; Other Serum Analytes —Glucose—.