Venient Fx Cardiovascular Function Comprehensive
Test Description
Venient Fx Cardiovascular Function Comprehensive is a disruptive, non-invasive test that provides comprehensive information on cardiovascular function.
It is based on routine blood analysis and is powered by both proprietary machine learning and public algorithms, and provides highly accurate broad diagnostic information, including the likelihood of cardiovascular disease. Specifically, this test is able to accurately detect atherogenic dyslipidemia and cardiovascular disease at all stages, and provides comprehensive information. In addition, it can also suggest the 10-year probability of developing cardiovascular disease.
It is based on a series of cardiovascular indices, which are made up by the combination of the different types of cholesterol and other analytes.
It is an Evidence Based Laboratory Medicine (EBML) test developed not only in accordance with American Heart Association (AHA) guidelines, but also incorporating the latest scientific findings.
Screening recommendations
The United States Preventative Services Task Force (USPSTF) recommends against electrocardiogram screening at rest or exercise to prevent cardiovascular disease (CVD) in asymptomatic adults at low risk for CVD.
However, Kience Inc. recommends the Venient Fx Cardiovascular Function Comprehensive test to treat patients with symptoms, signs or suspicion of disease: atherogenic dyslipidemia, type 2 diabetes mellitus (DM2), overweight, obesity, sedentary lifestyle, smoking or vaping, high blood pressure, hypothyroidism, Cushing's syndrome, chronic inflammatory disease (eg, SLE, rheumatoid arthritis or chronic obstructive pulmonary disease), metabolic syndrome, chronic kidney disease, abdominal obesity (waist circumference >94 cm in men or >80 cm in women) or familial hypercholesterolemia.
Intended Use
The target population for the Venient Fx Cardiovascular Function Comprehensive test are patients with clinical suspicion of: atherogenic dyslipidemia, type 2 diabetes mellitus (DM2), obesity, sedentary lifestyle, smoking or vaping, hypertension, hypothyroidism, Cushing's syndrome, chronic inflammatory disease (systemic lupus erythematosus (SLE), arthritis, psoriasis), alcoholism, metabolic syndrome, chronic kidney disease, abdominal obesity or familial hypercholesterolemia.
Sample Clinical Vignette
A 55-year-old male with a history of sedentary lifestyle, ex-smoker (AD 40 pack/year) with dyslipidemia and obesity presented for medical evaluation after a 1-week of dyspnea on exertion and intermittent episodes of shortness of breath. Physical exam revealed obesity (BMI 35 Kg/m2), hypertension (150/95 mmHg), mild tachycardia (102 bpm), and mild edema in the lower limbs. Serum is submitted to determine the lipid profile of the patient as well as his cardiovascular risk profile.
Required Laboratory Determinations
Serum Proteins —Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), Lipoprotein (a)—; Serum Sterols & Fatty Acids —Total Cholesterol, HDL-Cholesterol, Cholesterol non-HDL, LDL-Cholesterol, VLDL-Cholesterol, Triglycerides—; Other Serum Analytes —Bilirubin Total, Bilirubin Direct, Bilirubin Indirect—.