Venient Fx Hepatic Function Comprehensive
Test Description
Venient Fx Hepatic Function Comprehensive is a disruptive, non-invasive test that provides comprehensive information on liver and exocrine biliary-pancreatic function.
It is based on routine blood analysis and is powered by both proprietary machine learning and public algorithms, and provides highly accurate broad diagnostic information, including the likelihood of a wide range of liver-related diseases, e.g., hepatocellular (intrahepatic), cholestatic (extrahepatic) and mixed origin, offering comprehensive information. This test also calculates the 15-year risk of developing cirrhosis thanks to the chronic liver disease score (CLivD).
It is based on the combination of numerous calculations that allow the assessment of the degree of liver disease: non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver fibrosis, or liver cirrhosis.
It is an Evidence Based Laboratory Medicine (EBML) test developed not only in accordance with the guidelines of the American Association for the Study of Liver Diseases (AASLD), but also incorporating the latest scientific findings.
Screening recommendations
The United States Preventative Services Task Force (USPSTF) recommends screening for hepatitis C virus (HCV) infection in adults aged 18 to 79 years.
However, Kience Inc. recommends the Venient Fx Hepatic Function Comprehensive test for patients with symptoms, signs or suspicion of disease: hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis secondary to CMV/EBV, autoimmune hepatitis, drug-induced hepatitis, drug-induced liver injury (DILI), metabolic dysfunction associated with fatty liver disease (MAFLD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic fibrosis, liver cirrhosis, hemochromatosis, Wilson's disease, Gilbert's disease, cholestasis in patients with porto-pulmonary hypertension, hepatic cholestasis due to severe heart failure or acute pancreatitis (alcohol-related, drug-induced, gallstones or hypertriglyceridemia).
Intended Use
The target population for the Venient Fx Hepatic Function Comprehensive test is patients with symptoms, signs, or suspected disease: alcoholism-related hepatitis, hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis secondary to CMV/EBV, autoimmune hepatitis, drug-induced hepatitis, DILI, MAFLD, NAFLD, NASH, liver fibrosis, liver cirrhosis, hemochromatosis, Wilson's disease, Gilbert's disease, cholestasis, hepatic cholestasis due to severe heart failure, or acute pancreatitis.
Sample Clinical Vignette
A 58-year-old male, with persistent consumption of alcohol, presented a 6-month history of loss of appetite, jaundice, asthenia, weight loss, abdominal distention and easy bruising. Physical exam revealed generalized telangiectasis and ecchymosis on the chest and elbows, abdominal distention with presence of a wave sign and mild edema of the lower limbs. Serum is submitted to detect any hepatic disorder, including the stage of fatty liver disease and the risk of CLD (chronic liver disease).
Required Laboratory Determinations
Hemogram —Red Blood Cell Count, Hemoglobin, Hematocrit—; Red Blood Cell Indices —Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Blood Distribution Width (RDW)—; Leukocyte Count —Total Leukocytes Absolute, Total Neutrophil Absolute, Total Lymphocyte Absolute, Total Monocyte Absolute, Total Eosinophil Absolute, Total Basophil Absolute—; Platelets —Total Platelet Count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW)—; Coagulation —Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT); Serum Proteins —Albumin, Ferritin, Globulin, Total Protein—; Serum Hepatic Enzymes —Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase (LDH)—; Serum Sterols & Fatty Acids —Total Cholesterol, HDL-Cholesterol, Cholesterol non-HDL, LDL-Cholesterol, VLDL-Cholesterol, Triglycerides—; Serum Hormones —Insulin—; Other Serum Analytes —Bilirubin Total, Bilirubin Direct, Bilirubin Indirect, Serum Creatinine, Glucose, Glycated Hemoglobin (HbA1c)—.