Venient Fx Renal Function Basic
Test Description
Venient Fx Renal Function Basic is a disruptive and non-invasive test that provides primary information about the renal function of the patient.
It is based on a routine blood and urine analysis and powered by both public and machine learning (ML) proprietary algorithms, and it delivers high accurate primary diagnostic information including likelihood of having a kidney dysfunction. As a primary election test, the results of the parameters included on it are helpful in order to orientate through different diagnostic, prognostic and therapeutic options. Although normally the results are preliminary in decision making, in some cases, they can be definitive.
It is based on the glomerular filtration rate (GFR) with the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation and the urine albumin-to-creatinine ratio (urine ACR).
In case of a positive result, the diagnostic report can suggest performing a certain secondary election test, in order to deepen the diagnostic information, confirm therapies, establish prognostics or perform the follow-up of the disease.
If a renal disfunction is suggested, others tests will be recommended according to convenience.
Screening Recommendations
The United States Preventative Services Task Force (USPSTF) does not include any recommendations for screening for kidney disease.
However, Kience Inc. recommends the Venient Fx Renal Function Basic test to treat patients with the following symptoms, signs, or suspected disease: acute kidney injury; chronic kidney disease; drug-induced acute kidney injury; heart failure; high blood pressure; type 2 diabetes mellitus (DM2); volume depletion due to dehydration or bleeding; nephrolithiasis; acute pyelonephritis; polycystic kidney disease; renal artery occlusion; vasculitis; glomerulonephritis; or autoimmune diseases (e.g., SLE or scleroderma), among others.
Intended Use
The intended population for Venient Fx Renal Function Basic test are patients with clinical suspicion of: acute or drug-induced kidney injury; chronic kidney disease; renal dysfunction due to heart failure; renal dysfunction due to arterial hypertension, vasculitis or type 1 or type 2 diabetes mellitus; volume depletion due to dehydration or hemorrhage; nephrolithiasis; acute pyelonephritis; polycystic kidney disease; renal artery occlusion; glomerulonephritis or autoimmune diseases.
Sample Clinical Vignette
A 76-year-old-male with history of hypertension on treatment for the past 20 years, and Type 2 Diabetes Mellitus on insulin for the past 15 years, visits his primary care physician because of persistent bilateral swelling/edema on both limbs, loss of appetite and metallic taste. On physical exam, blood pressure was 165/56 and bradycardic (HR 48 bpm), swelling in the lower extremities goes up until the knee (feet, ankles) level and also involves abdomen.
Required Laboratory Determinations
Other Serum Analytes —Serum Creatinine—; Other Urine Analytes —Urine Albumin, Urine Creatinine—.