Venient Fx Renal Function Comprehensive
Test Description
Venient Cx Renal Function Comprehensive is a groundbreaking blood and urine based screening test that provides extensive information about renal function.
This is an Evidence-Based Laboratory Medicine (EBLM) test developed not only in compliance with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) guidelines, but also incorporating the latest scientific findings. Thanks to our proprietary machine learning (ML) algorithms, this test is able to accurately detect chronic kidney disease (CKD) in all stages, and delivers comprehensive information including likelihood of having renal function disorders according to the creatinine equation — recommended by the National Kidney Foundation (NKF). This test also calculates the 2-year and 5-year risk of developing kidney failure for all CKD grade G3-G5 results thanks to the Kidney Failure Risk Equation (KFRE).
United States Preventative Services Task Force (USPSTF) screening recommendations
The USPSTF has no recommendation for kidney disease screening. However, Kience Inc. recommends our laboratory-developed test (LDT) Venient Cx Renal Function Comprehensive to target patients with clinical suspicion of: acute kidney injury, chronic kidney disease (CKD), drug-induced acute kidney injury (AKI), renal dysfunction due to heart failure, renal dysfunction due to arterial hypertension, renal dysfunction due to type 1 diabetes mellitus (DM1), renal dysfunction due to type 2 diabetes mellitus (DM2), volume depletion due to dehydration or hemorrhage, nephrolithiasis, acute pyelonephritis, polycystic kidney disease, renal artery occlusion, renal dysfunction due to vasculitis, glomerulonephritis or autoimmune diseases (e.g. SLE or scleroderma), among others.
Intended Use
The intended population for Venient Cx Renal Function Comprehensive test are patients with clinical suspicion of: acute or drug-induced kidney injury; chronic kidney disease; renal dysfunction due to heart failure; renal dysfunction due to arterial hypertension, vasculitis or type 1 or type 2 diabetes mellitus; volume depletion due to dehydration or hemorrhage; nephrolithiasis; acute pyelonephritis; polycystic kidney disease; renal artery occlusion; glomerulonephritis or autoimmune diseases.
Sample Clinical Vignette
A 55-year-old male with a >10 years history of hypertension and poorly controlled type 2 diabetes mellitus, presented for his medical evaluation after a 3-month history of loss of appetite, nausea, generalized itching and edema of the lower limbs with decreased urinary volume. Physical exam revealed pallor with mild edema in lower limbs. Serum and urine are submitted to detect renal dysfunction and also to assess the risk of CKD (chronic kidney disease).
Required Laboratory Determinations
Serum Electrolytes —Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium—; Serum Proteins —Albumin—; Other Serum Analytes —Serum Creatinine, Glucose—; Other Urine Analytes —Urine Albumin, Urine Creatinine—; Urinalysis —Density, pH, White Blood Cells, Nitrites, Protein, Glucose, Ketones, Urobilinogen, Urobilin, Red Blood Cells, Urine Sediment—.