Venient Fx Iron Function Comprehensive
Test Description
Venient Fx Iron Function Comprehensive is a disruptive, non-invasive test that provides extensive information on iron transport and storage.
It is based on routine blood analysis and powered by both proprietary machine learning and public algorithms, and provides highly accurate broad diagnostic information, including the likelihood of anemia and identifying the three main types: microcytic, normocytic and macrocytic. It can also suggest the cause, such as iron deficiency anemia, anemia of chronic disease, or vitamin B12 deficiency anemia, among others.
It is based on the soluble transferrin receptor (sTfr)/ferritin ratio, transferrin saturation, total iron binding capacity (TIBC) and unsaturated iron binding capacity (UIBC). It also includes other determinations such as hepatic enzymes, the different types of cholesterols, glucose, creatinine, urea, blood urea nitrogen (BUN) and uric acid.
It is an Evidence Based Laboratory Medicine (EBML) test developed not only in compliance with the guidelines of the American Society of Hematology (ASH), but also incorporating the latest scientific findings.
Screening recommendations
The United States Preventative Services Task Force (USPSTF) recommends routine screening for iron deficiency anemia in asymptomatic pregnant women.
However, Kience Inc. recommends the Venient Fx Iron Function Comprehensive test to treat patients with the following symptoms, signs, or clinical suspicion of: iron deficiency, vitamin B12 deficiency, folic acid deficiency, hemolytic anemia, chronic kidney disease, myelodysplastic syndromes, anemia of chronic disease, dietary deficiencies, hypothyroidism, celiac disease, gastrointestinal angiodysplasia, atrophic gastritis, bone marrow aplasia, myelophthisic anemia, chronic liver disease, hypersplenism, thrombotic microangiopathy, mechanical hemolysis caused by prosthetic valve dysfunction or thalassemia, among others.
Intended Use
The target population for the Venient Fx Iron Function Comprehensive test are patients with clinical suspicion of: iron deficiency, vitamin B12 deficiency, folic acid deficiency, hemolytic anemia, chronic kidney disease, chronic kidney disease, myelodysplastic syndromes, ACD, hypothyroidism, celiac disease, gastrointestinal angiodysplasia, marrow aplasia, myelophthisic anemia, alcoholism, CLD, hypersplenism, thrombotic microangiopathy, mechanical hemolysis caused by prosthetic valve dysfunction, or thalassemia.
Sample Clinical Vignette
A 42-year-old woman came for consultation after 3 months of asthenia, pallor, hair loss, exertional dyspnea and palpitations. She does not report weight loss, dark stools or constipation. Physical examination showed normal vital signs, except for mild tachycardia (104 bpm), mucocutaneous pallor and nail fragility. Recent blood tests showed a hemoglobin of 7 g/dl. Serum is sent to determine if the patient is anemic, including type and etiology.
Required Laboratory Determinations
Hemogram —Red Blood Cell Count, Total Reticulocytes, Hemoglobin, Hematocrit—; Red Blood Cell Indices —Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Blood Distribution Width (RDW)—; Leukocyte Count —Total Leukocytes Absolute, Total Neutrophil Absolute, Total Lymphocyte Absolute, Total Monocyte Absolute, Total Eosinophil Absolute, Total Basophil Absolute—; Platelets —Total Platelet Count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW)—; Serum Proteins —High Sensitivity C-Reactive Protein (hs-CRP), Ferritin, Soluble Transferrin Receptor (sTfr), Total Iron Binding Capacity (TIBC), Unsaturated Iron Binding Capacity (UIBC), Transferrin—; Serum Hepatic Enzymes —Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase (LDH)—; Serum Sterols & Fatty Acids —Total Cholesterol, HDL-Cholesterol, Cholesterol non-HDL, LDL-Cholesterol, VLDL-Cholesterol, Triglycerides—; Serum Hormones —Thyroid-Stimulating Hormone (TSH), Thyroxine Free (T4 Free)—; Serum Vitamins —Folate in Red Blood Cells, Vitamin B12—; Other Serum Analytes —Bilirubin Total, Bilirubin Direct, Bilirubin Indirect, Serum Creatinine, Glucose, Serum Iron, Urea, Blood Urea Nitrogen, Uric Acid—.