Venient Fx Iron Function Comprehensive
Test Description
Venient Cx Iron Function Comprehensive is a groundbreaking blood-based screening test that provides extensive information about iron transport and storage.
This is an Evidence-Based Laboratory Medicine (EBLM) test developed not only in compliance with the American Society of Hematology (ASH) guidelines, but also incorporating the latest scientific findings.
Thanks to our proprietary machine learning (ML) algorithms, this test is able to accurately detect the three main anemia types — microcytic, normocytic, and macrocytic. It can also suggest the cause, such as iron-deficiency anemia (IDA), anemia of chronic disease (ACD), or vitamin B12-deficiency anemia, among others.
United States Preventative Services Task Force (USPSTF) screening recommendations
The USPSTF recommends routine screening for iron deficiency anemia in asymptomatic pregnant women. However, Kience Inc. recommends our laboratory-developed test (LDT) Venient Cx Iron Function Comprehensive to address patients with clinical suspicion of: iron deficiency, vitamin B12 deficiency, folic acid deficiency, hemolytic anemia, chronic kidney disease, myelodysplastic syndromes, anemia of chronic diseases (ACD), dietary deficiencies, hypothyroidism, celiac disease, gastrointestinal angiodysplasia, atrophic gastritis, medullary aplasia, myelophthisic anemia, chronic liver disease (CLD), hypersplenism, thrombotic microangiopathy, mechanical hemolysis caused by prosthetic valve dysfunction or thalassemia, among others.
Intended Use
The intended population for Venient Cx Iron Function Comprehensive test are patients with clinical suspicion of: iron deficiency, vitamin B12 deficiency, folic acid deficiency, hemolytic anemia, chronic kidney disease, myelodysplastic syndromes, ACD, hypothyroidism, celiac disease, gastrointestinal angiodysplasia, medullary aplasia, myelophthisic anemia, alcoholism, CLD, hypersplenism, thrombotic microangiopathy, mechanical hemolysis caused by prosthetic valve dysfunction, or thalassemia.
Sample Clinical Vignette
A 42-year-old female presented for medical evaluation after a 3-month history of asthenia, paleness, hair loss, dyspnea on exertion and palpitations. She does not report weight loss, dark stools or constipation. Physical exam showed normal vital signs except for mild tachycardia (104 bpm), mucocutaneous pallor and nail fragility. Recent blood tests showed Hemoglobin of 7 g/dl. Serum is submitted to determine if the patient is anemic including the type and etiology.
Required Laboratory Determinations
Hemogram —Red Blood Cell Count, Total Reticulocytes, Hemoglobin, Hematocrit—; Red Blood Cell Indices —Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Red Cell Blood Distribution Width (RDW)—; Leukocyte Count —Total Leukocytes Absolute, Total Neutrophil Absolute, Total Lymphocyte Absolute, Total Monocyte Absolute, Total Eosinophil Absolute, Total Basophil Absolute—; Platelets —Total Platelet Count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW)—; Serum Proteins —High Sensitivity C-Reactive Protein (hs-CRP), Ferritin, Soluble Transferrin Receptor (sTfr), Total Iron Binding Capacity (TIBC), Unsaturated Iron Binding Capacity (UIBC), Transferrin—; Serum Hepatic Enzymes —Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT), Lactate Dehydrogenase (LDH)—; Serum Sterols & Fatty Acids —Total Cholesterol, HDL-Cholesterol, Cholesterol non-HDL, LDL-Cholesterol, VLDL-Cholesterol, Triglycerides—; Serum Hormones —Thyroid-Stimulating Hormone (TSH), Thyroxine Free (T4 Free)—; Serum Vitamins —Folate in Red Blood Cells, Vitamin B12—; Other Serum Analytes —Bilirubin Total, Bilirubin Direct, Bilirubin Indirect, Serum Creatinine, Glucose, Serum Iron, Urea, Blood Urea Nitrogen, Uric Acid—.