Venient Fx Renal Function Comprehensive
Test Description
Venient Fx Renal Function Comprehensive is a disruptive, non-invasive test that provides comprehensive information on kidney function.
It is based on routine blood and urine analysis and is powered by both proprietary machine learning and public algorithms, and provides highly accurate comprehensive diagnostic information, being able to accurately detect chronic kidney disease at all stages, and provides comprehensive information, including the probability of having kidney function disorders according to the creatinine equation —recommended by the National Kidney Foundation (NKF). This test also calculates the 2- and 5-year risk of developing kidney failure for all CKD grade G3-G5 results thanks to the Kidney Failure Risk Equation (KFRE).
It is based on corrected calcium, corrected chloride, corrected magnesium, corrected potassium, corrected sodium, corrected calcium/phosphate ratio and other measures such as glomerular filtration rate, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation and urine albumin/creatinine ratio (urine ACR).
It is an Evidence Based Laboratory Medicine (EBML) test developed not only in accordance with CKD-EPI guidelines, but also incorporating the latest scientific findings.
Screening recommendations
The United States Preventative Services Task Force (USPSTF) does not recommend screening for kidney disease.
However, Kience Inc. recommends the Venient Fx Renal Function Comprehensive test for patients with symptoms, signs or suspicion of disease: acute kidney injury, chronic kidney disease, drug-induced acute kidney injury, renal dysfunction due to heart failure, renal dysfunction due to high blood pressure, renal dysfunction due to type 1 diabetes mellitus (DM1), renal dysfunction due to type 2 diabetes mellitus (DM2), volume depletion due to dehydration or hemorrhage, nephrolithiasis, acute pyelonephritis, polycystic kidney disease, renal artery occlusion, renal dysfunction due to vasculitis, glomerulonephritis or autoimmune diseases —e.g. systemic lupus erythematosus (SLE) or scleroderma—, among others.
Intended Use
The target population for the Venient Fx Renal Function Comprehensive test is patients with symptoms, signs or suspicion of disease: acute or drug-induced kidney injury, chronic kidney disease, renal dysfunction due to heart failure, renal dysfunction due to arterial hypertension, vasculitis or type 1 or type 2 diabetes mellitus, volume depletion due to dehydration or bleeding, nephrolithiasis, acute pyelonephritis, polycystic kidney disease, renal artery occlusion, glomerulonephritis, or autoimmune diseases.
Sample Clinical Vignette
A 55-year-old male with a >10 years history of hypertension and poorly controlled type 2 diabetes mellitus, presented for his medical evaluation after a 3-month history of loss of appetite, nausea, generalized itching and edema of the lower limbs with decreased urinary volume. Physical exam revealed pallor with mild edema in lower limbs. Serum and urine are submitted to detect renal dysfunction and also to assess the risk of CKD (chronic kidney disease).
Required Laboratory Determinations
Serum Electrolytes —Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium—; Serum Proteins —Albumin—; Other Serum Analytes —Serum Creatinine, Glucose—; Other Urine Analytes —Urine Albumin, Urine Creatinine—; Urinalysis —Density, pH, White Blood Cells, Nitrites, Protein, Glucose, Ketones, Urobilinogen, Urobilin, Red Blood Cells, Urine Sediment—.